发明名称 |
Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors |
摘要 |
The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.
|
申请公布号 |
US2003176642(A1) |
申请公布日期 |
2003.09.18 |
申请号 |
US20030354706 |
申请日期 |
2003.01.30 |
申请人 |
GYORKOS ALBERT;SPRUCE LYLE;OHMOTO KAZUYUKI;KAWABATA KAZUHITO |
发明人 |
GYORKOS ALBERT;SPRUCE LYLE;OHMOTO KAZUYUKI;KAWABATA KAZUHITO |
分类号 |
A61K38/00;A61K38/55;A61P9/10;A61P11/00;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P25/28;A61P27/02;A61P27/16;A61P31/04;A61P35/00;A61P37/06;A61P43/00;C07D271/10;C07D413/12;C07D413/14;C07D417/12;C07K5/02;C07K5/06;C07K5/062;C07K5/065;C07K5/068;C07K5/072;C07K5/078;C07K5/083;C07K5/12;C12N9/99;(IPC1-7):C07K5/04;C07D413/02 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|