Process for preparing alpha-hydroxyamides and alpha-ketoamides on a solid phase support

摘要

The present invention relates to a process for preparing a alpha-hydroxyamide or alpha-ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide with an aldehyde in the presence of a catalyst, to form a resin-bound alpha-hydroxyamide; b) optionally reacting said resin-bound alpha-hydroxyamide with a reagent which is capable of oxidizing said resin-bound alpha-hydroxyamide to a resin-bound alpha-ketoamide; and c) reacting said resin-bound alpha-hydroxyamide or resin-bound alpha-ketoamide with a reagent which cleaves the nitrogen-resin bond to form a alpha-hydroxyamide alpha-ketoamide.