发明名称 |
Diagnostics and therapeutic uses of topors |
摘要 |
Topors and topors antibody can be used to manipulate the presence and function of both Top1 and p53 in cells, thus controlling the function of the Top1 and p53 proteins. Topors is implicated in prevention of tumorigenesis through its role in DNA repair and preventing faulty or mutated DNA from replicating. Topors can be used therapeutically as a medicament and topors DNA can be used in gene therapy. Topors antibody may be used to detect the presence of cancer by screening for the absence of topors in a given cell or tissue sample. Kits comprising the topors antibody are also contemplated.
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申请公布号 |
US2003176343(A1) |
申请公布日期 |
2003.09.18 |
申请号 |
US20030339924 |
申请日期 |
2003.01.09 |
申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
RUBIN ERIC H.;SALEEM AHAMED;RASHEED ZESHAAN;HALUSKA PAUL |
分类号 |
A61K38/17;A61K48/00;C07K14/47;C07K16/18;C07K16/40;C12Q1/68;G01N33/574;(IPC1-7):C12Q1/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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