METHODS FOR ALZHEIMER'S DISEASE TREATMENT AND COGNITIVE ENHANCEMENT

摘要

The present invention relates to compositions and methods to modulate .alpha .- secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularl y Alzheimer's Disease patients, and treatment thereof through increased sAPP production. Macrocyclic lactones (i.e. bryostatin class and neristatin class ) are compounds preferred for use with the present composition. The present invention also provides methods for increasing the generation of non- amyloidogenic soluble APP comprising the activation of protein kinase C (PKC ) by administering an effective amount of PKC activator(s).