发明名称 |
A NON-HORMONAL APPROACH TO MALE CONTRACEPTION |
摘要 |
The present invention provides a method by which to reversibly render male mammals infertile. Thus, the disclosed N-substituted imino compounds, and pharmaceutical compositions thereof, completely impair the fertility of male mammals, but exhibit no effect on that of female mammals, and are thus usefu l as male contraceptives. Particularly efficacious compounds are imino sugars derived from N-alkylated piperidines of the formulae: wherein R2 is can be a linear or branched C1-18 alkyl, C2-18 alkenyl or alkynyl; or aralkyl; which may be optionally substituted with one or more of -OH; -F; -CI; -Br; -I; -NH 2; alkyl- and dialkylamino; linear or branched C1-6 alkyl, C2-6 alkenyl and alkynyl; aralkyl; linear or branched C1-6 alkoxy, aryloxy; aralkoxy; -CN, - NO2, -COOH, -COO(alkyl); -COO(aryl); - C(O)NH(C1-6 alkyl); -C(O)NH(aryl); sulfonyl; (C1-6 alkyl)sulfonyl; arylsulfonyl; sulfamoyl, (C1-6 alkyl)sulfamoyl; (C1-6 alkyl)thio; (C1-6 alkyl)sulfonamide; arylsulfonamide; - NHNH2; and -NHOH.
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申请公布号 |
CA2479027(A1) |
申请公布日期 |
2003.09.18 |
申请号 |
CA20032479027 |
申请日期 |
2003.03.13 |
申请人 |
VAN DER SPOEL, AARNOUD C. |
发明人 |
PLATT, FRANCES, M.;JEYAKUMAR, MYLVAGANAM;BUTTERS, TERRY, D.;DWEK, RAYMOND, A.;VAN DER SPOEL, AARNOUD C. |
分类号 |
C07D211/46;A61K31/40;A61K31/4015;A61K31/4025;A61K31/445;A61K31/454;A61P15/16;(IPC1-7):A61K31/40 |
主分类号 |
C07D211/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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