ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES (ESACHEL)

摘要

The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or function al analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capab le of performing a combination reaction with at least one self-assembly sequenc e (b1') of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p ) is characterized in that the chemical compound further comprises at least on e self-assembly moiety (m) capable of performing a combination reaction with a t least one self-assembly moiety (m') of a similar chemical compound comprisin g a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.