PROCESS FOR PRODUCING OPTICALLY ACTIVE SULFOXIDE DERIVATIVE

摘要

A process for producing an optically active sulfoxide derivative (I) having CCR5 antagonistic activity without causing side reactions such as racemizati on and Pummerer rearrangement, which comprises reacting a compound (II) with a compound (III) as shown by the following scheme. (II) + (III) (I) In the scheme, R1 represents hydrogen, an aliphatic hydrocarbon group, or an aromat ic group; R2 represents halogeno, alkyl, hydroxy, amino, an aromatic group, etc .; R3 represents a 5- or 6-membered ring; R4 represents hydrogen, alkyl, alkoxy , or halogeno; R5 represents hydrogen, a hydrocarbon group, a heterocyclic group, acyl, etc.; ring A represents an optionally substituted benzene ring; X represents a bond or divalent group comprising a linear part constituted of one to four atoms; m is an integer of 1 to 5; n is an integer of 0 to 3; p i s an integer of 0 to 2; and *1 indicates an asymmetric center.