发明名称 |
METHOD OF INDUCING AN ENHANCED IMMUNE RESPONSE AGAINST HIV |
摘要 |
<p>An efficient means of inducing an immune response against human immunodeficiency virus ("HIV") utilizing specific prime-boost regimes is disclosed. The specific prime-boost regimes employ a heterologous prime-boost protocol wherein recombinant adenoviral and poxvirus vectors comprising exogenous genetic material encoding a common HIV antigen are administered in that order. Vaccines administered into living vertebrate tissue in accordance with the disclosed regimes, preferably a mammalian host such as a human or a non-human mammal of commercial or domestic veterinary importance, express the HIV-1 antigen (e.g., Gag), inducing a cellular immune response which specifically recognizes HIV-1. It is believed that the disclosed prime/boost regime will offer a prophylactic advantage to previously uninfected individuals and/or provide a therapeutic effect by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV-1 infection.</p> |
申请公布号 |
CA2478631(A1) |
申请公布日期 |
2003.09.18 |
申请号 |
CA20032478631 |
申请日期 |
2003.03.12 |
申请人 |
MERCK & CO., INC. |
发明人 |
CHASTAIN, MICHAEL;EMINI, EMILIO A.;CASIMIRO, DANILO R.;FU, TONG-MING;LIANG, XIAOPING;SHIVER, JOHN W. |
分类号 |
A61K39/21;C07K14/16;C12N15/861;C12N15/863;(IPC1-7):A61K39/21 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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