| 摘要 |
<p>The present invention relates to isolated nucleic acid molecules encoding splice variants LATS2b and LATS2c, isolated LATS2b and LATS2c protein or polypeptides, and antibodies to the LATS2b and LATS2c proteins or polypeptides. The present invention also relates to methods of using the LATS2b and LATS2c nucleic acid molecules and proteins or polypeptides, including for detecting the expression of LATS2b or LATS2c in a biological sample, regulating LATS2b or LATS2c expression, screening drugs that regulate LATS2b or LATS2c activity and expression, regulating cell growth and differentiation, and treating disease conditions in a subject. Also disclosed are expression vectors, host cells, and transgenic animals transformed with LATS2b and LATS2c nucleic acid molecules.</p> |
