发明名称 |
Continuous production of 5-alkoxy oxazoles useful as vitamin B6 intermediates, comprises heating an alkyl alpha-isocyanoalkanoate ester in the presence of an auxiliary agent |
摘要 |
<p>Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha-isocyanoalkanoate ester (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha-isocyanoalkanoate ester of formula (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.</p> |
申请公布号 |
DE10209447(A1) |
申请公布日期 |
2003.09.18 |
申请号 |
DE2002109447 |
申请日期 |
2002.03.05 |
申请人 |
BASF AG |
发明人 |
KINDLER, ALOIS;RUST, HARALD;BURKART, KIRSTEN;KNOLL, CHRISTIAN;HENKELMANN, JOCHEM |
分类号 |
C07D213/66;B01D3/14;B01J14/00;C07D213/67;C07D263/42;(IPC1-7):C07D263/42;C07B37/12 |
主分类号 |
C07D213/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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