| 发明名称 |
USE OF PERICYTE APOPTOSIS INHIBITORS FOR TREATING AND/OR PREVENTING DIABETIC RETINOPATHY |
| 摘要 |
The use of a retinal pericyte apoptosis inhibitor (I) is claimed in the production of a medicament for treating or preventing diabetic retinopathy. An independent claim is included for pharmaceutical compositions containing (I). - ACTIVITY : Antidiabetic; Ophthalmological. - MECHANISM OF ACTION : Retinal pericyte apoptosis inhibitor; Antioxidant; Phosphatidylcholine phospholipase C inhibitor; Acid sphingomyelinase inhibitor; Caspase inhibitor. In tests in cultured bovine pericytes, tricyclo (5,21,0(2,6)) decyl-9(8)-xanthate (D609) (Ia) at a concentration of 9.4 MicroM inhibited advanced glycosylation end product (AGE)-methylglyoxal induced ceramide production by 95%, diacyl glycerol (DAG) production by 80% and apoptosis by 40%. |
| 申请公布号 |
EP1343491(A2) |
申请公布日期 |
2003.09.17 |
| 申请号 |
EP20010982545 |
申请日期 |
2001.10.24 |
| 申请人 |
MERCK SANTE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
LECOMTE, MARC;DENIS, ULRICHE;PAGET, CLARISSE;WIERNSPERGER, NICOLAS;LAGARDE, MICHEL |
| 分类号 |
A61K31/195;C12N15/09;A61K31/00;A61K31/047;A61K31/07;A61K31/13;A61K31/185;A61K31/19;A61K31/198;A61K31/385;A61K31/405;A61K31/41;A61K31/495;A61K31/55;A61K31/555;A61K31/7088;A61K38/00;A61K38/06;A61K38/07;A61K38/08;A61K38/43;A61K38/55;A61K38/57;A61K45/00;A61K45/06;A61K48/00;A61P3/10;A61P27/02;C12Q1/02;(IPC1-7):A61K31/195;A61K31/645 |
主分类号 |
A61K31/195 |
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