| 摘要 |
A pharmaceutical composition comprising a novel pyridine compound is provided to prevent or treat inflammatory and immune diseases by inhibiting adhesion reaction of inflammatory cells and cell adhesion molecules. A pharmaceutical composition for treating and preventing inflammatory and immune diseases comprises a pyridine compound represented by a formula(1) and having cell adhesion molecules generation inhibitory and cell adhesion inhibitory activities or a pharmaceutically acceptable salt thereof, wherein the inflammatory and immune disease is selected from the group consisting of rheumatoid arthritis, asthma, dermatitis, psoriasis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel disease, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary diseases(COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina, cancer metastasis and arteries disorder. In the formula(1), each R1, R2, R3, R4, and R5 is independently selected from the group consisting of H, halo, cyano, nitro, acyl, hydroxy, amino, C1-6 alkyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkylthio, C1-10 alkylamino, C4-9 cycloalkylamino, C4-9 heterocycloalkylamino, arylamino, acylamino, acyloxy, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkylsulfonylamino, arylsulfinyl, arylsulfonyl, arylsulfonylamino, aryl, heteroaryl, C1-10 aralkyl, C1-10 heteroaralkyl, aryloxy and heteroaryloxy, or R1, R2, R3, R4 or R5 may form a ring with a substituent adjacent to one another; X is O or S; Y is O or N-R6(wherein R6 is H, C1-6 alkyl, acyl, aryl, heteroaryl, C1-10 aralkyl, or C1-10 heteroaralkyl or may form a ring with the R5).
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