发明名称 |
IMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE |
摘要 |
The present invention is directed to an imide compound of the formula: (see Formula I) wherein Z is a group of the formula: (see Formula II) in which B is a carbonyl group or a sulfonyl group, R1, R2, R3 and R4 each represent a hydrogen atom or a lower alkyl group, or R1 and R2 or R1 and R3 may be combined together to form a non-aromatic hydrocarbon ring or R1 and R3 may be combined together to form an aromatic ring, said non-aromatic hydrocarbon ring being optionally bridged with a lower alkylene group or an oxygen atom therein and said aromatic ring, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and n is an integer of 0 or 1; D is a group of the formula: -(CH2)p-A-(CH2)q- in which A is a non-aromatic hydrocarbon ring optionally bridged with a lower alkylene group or an oxygen atom, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and p and q are each an integer of 0, 1 or 2; and -2- Ar is an aromatic group, a heterocyclic aromatic group, a benzoyl group, a phenoxy group or a phenylthio group and G is ~N-, ~CH- or ~COH- or Ar is a biphenyl- methylidene group and G is ~C=, all of the above groups beingeach optionally substituted with at least one of lower alkyl, lower alkoxy and halogen; and its acid addition salts. The compounds of the present invention are useful as an antipsychotic agent.
|
申请公布号 |
CA2046429(C) |
申请公布日期 |
2003.09.16 |
申请号 |
CA19912046429 |
申请日期 |
1991.07.05 |
申请人 |
MUTO, MASAYUKI;SAJI, IKUTARO;YOSHIGI, MAYUMI;TANNO, NORIHIKO |
发明人 |
MUTO, MASAYUKI;SAJI, IKUTARO;YOSHIGI, MAYUMI;TANNO, NORIHIKO |
分类号 |
A61K31/445;A61K31/4427;A61K31/443;A61K31/47;A61K31/495;A61K31/505;A61P25/18;A61P25/20;C07D207/40;C07D209/48;C07D209/54;C07D209/76;C07D221/20;C07D275/06;C07D401/08;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D413/12;C07D417/08;C07D417/12;C07D417/14;C07D487/04;C07D491/18;C07D493/08;(IPC1-7):C07D417/14;C07D403/08;C07D403/14;C07D405/14;C07D413/14 |
主分类号 |
A61K31/445 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|