发明名称 |
NOVEL CARBOXYALKYL DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
摘要 |
The present invention relates to compounds of the formula (see Formula I) wherein B1 and B2 are each independently hydrogen; hydroxy; -OR2 wherein R2 is a C1-C4 alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C1-C4 alkyl; or, where B1 and B2 are attached to adjacent carbon atoms, B1 and B2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy; A is a bond, methylene or oxygen, sulfur or NR4 or NCOR5 wherein R4 is hydrogen, a C1-C4 alkyl or an Ar-Y- group and R5 is -CF3, a C1-C10 alkyl or an Ar-Y- group; R3 is hydrogen or -CH2OC(O)C(CH3)3; R1 is hydrogen, C1-C4 alkyl or -CH2OC(O)-C(CH3)3; and n is an integer 1 to 3, which are useful as inhibitors of enkephalinase and ACE.
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申请公布号 |
CA2078759(C) |
申请公布日期 |
2003.09.16 |
申请号 |
CA19922078759 |
申请日期 |
1992.09.21 |
申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
WARSHAWSKY, ALAN M.;FLYNN, GARY A. |
分类号 |
A61K31/535;A61K31/54;A61K31/55;A61K38/00;A61P7/10;A61P9/00;A61P9/12;A61P25/04;A61P25/28;A61P43/00;C07D471/04;C07D487/04;C07D498/04;C07D507/00;C07D513/04;C07K5/078;(IPC1-7):C07D471/04;C07D491/147 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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