A transformant with an increased rate of L-lysine production and secretion is obtained by introducing into a corynebacterium a recombinant DNA that can be replicated in a corynebacterium and contains either a DNA fragment originating in a corynebacterium and coding for an aspartokinase alpha -subunit protein whereby a synergistic feedback inhibition by L-lysine and L-threonine is released or a DNA fragment originating in a corynebacterium and coding for an aspartokinase beta -subunit protein whereby a synergistic feedback inhibition by L-lysine and L-threonine is released. The obtained transformant is cultured in a suitable medium and the formed L-lysine is separated. <MATH>
申请公布号
DK0699759(T3)
申请公布日期
2003.09.15
申请号
DK19940902116T
申请日期
1993.12.14
申请人
AJINOMOTO CO., INC.
发明人
SUGIMOTO, MASAKAZU, CENTRAL RES. LAB.;OGAWA, YURI, CENTRAL RES. LAB.;SUZUKI, TOMOTO, CENTRAL RES. LAB.;TANAKA, AKIKO, CENTRAL RES. LAB.;MATSUI, HIROSHI, CENTRAL RES. LAB.