发明名称 |
Oral formulation comprising an inhibitor compound of the ileal bile transport and an HMG Co-A reductase inhibitor. |
摘要 |
An oral pharmaceutical formulation comprising an inhibitor compound of the ileal bile acid transport (IBAT inhibitor), an HMG Co-A reductase inhibitor and a therapeutically acceptable carrier characterised in that the formulation is designed to deliver the IBAT inhibitor in the ileum and the HMG Co A reductase inhibitor non-specifically into the GI tract. The IBAT inhibitor compound and the HMG Co-A reductase inhibitor can also be administered in combination with a bile acid binder to alleviate possible side effects of therapy with IBAT inhibitor compounds, such as for instance diarrhoea. The bile acid binder may be formulated for colon release. |
申请公布号 |
ZA200204771(B) |
申请公布日期 |
2003.09.15 |
申请号 |
ZA20020004771 |
申请日期 |
2002.06.13 |
申请人 |
ASTRAZENECA AB. |
发明人 |
INGEMAR STARKE;ANNA-LENA UNGELL;BERTIL ABRAHAMSSON;ANN-MARGRET LINDQVIST |
分类号 |
A61K9/22;A61K9/14;A61K9/50;A61K31/00;A61K31/40;A61K31/505;A61K31/554;A61K45/00;A61K45/06;A61K47/30;A61P1/12;A61P3/06 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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