发明名称 |
BENZIMIDAZOLE , PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS OF GABA RECEPTORS, PHARMACEUTICAL COMPOSITION BASED THEREON, A METHOD FOR THE PREPARATION THEREOF |
摘要 |
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of formula (I). The invention is particularly related to such compounds that bind with high selectivity and high affinity lo the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections. (I)
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申请公布号 |
UA75902(C2) |
申请公布日期 |
2003.09.15 |
申请号 |
UA20030065755 |
申请日期 |
2001.12.21 |
申请人 |
NEWPOGEN CORPORATION;PFIZER INC. |
发明人 |
PETERSON JOHN M.;CURRIE KEVIN S.;GUSTAVSON LINDA M.;MAYNARD GEORGE D.;LUKE GEORGE P.;ALLEN MARTIN PATRICK |
分类号 |
A61K31/415;A61K31/4184;A61K31/4196;A61K31/422;A61K31/4245;A61K31/435;A61K31/437;A61K31/438;A61K31/4439;A61K31/454;A61K31/506;A61K31/5377;A61K31/541;A61K31/55;A61P25/00;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;C07D233/20;C07D233/54;C07D401/04;C07D401/14;C07D403/04;C07D403/06;C07D403/14;C07D405/04;C07D405/14;C07D409/14;C07D413/06;C07D413/14;C07D417/04;C07D417/06;C07D417/14;C07D471/04;C07D473/00;C07D491/08;C07D491/10;C07D491/113 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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