| 发明名称 |
CONJUGATES OF THE C DOMAIN OF HUMAN GELATINASE A AND POLYETHYLENE GLYCOL, METHODS OF PURIFICATION AND USES THEREOF |
| 摘要 |
A conjugate comprising the C domain of human gelatinase A (PEX domain, PEX) and one to three poly(ethylene glycol) groups), said poly(ethylene glycol) group(s) having an overall molecular weight of from about 10 to 40 kDa and being conjugated via primary amino group(s) of said PEX is useful for the treatment of cancer.
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| 申请公布号 |
CA2475370(A1) |
申请公布日期 |
2003.09.12 |
| 申请号 |
CA20032475370 |
申请日期 |
2003.02.28 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
DIMOUDIS, NIKOLAOS;SCHEUER, WERNER;LANZENDOERFER, MARTIN;KOPETZKI, ERHARD |
| 分类号 |
C12N15/09;A61K38/00;A61K38/48;A61K47/48;A61P35/00;C12N9/64;(IPC1-7):A61K47/48 |
主分类号 |
C12N15/09 |
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