发明名称 |
PROTEINS, GENES AND THEIR USE FOR DIAGNOSIS AND TREATMENT OF VASCULAR RESPONSE |
摘要 |
The present invention provides methods and compositions for screening, diagnosis and prognosis of vascular response, for monitoring the effectiveness of vascular response treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. In particular, the screening of drug candidates for their ability to induce a vascular response, Vascular Response-Associated Features (VRFs), detectable by two-dimensional electrophoresis of blood, serum or plasma are described. The invention further provides Vascular Response-Associated Protein Isoforms (VRPIs) detectable in blood, serum or plasma, preparations comprising isolated VRPIs, antibodies immunospecific for VRPIs, and kits comprising the aforesaid. |
申请公布号 |
WO02054080(A3) |
申请公布日期 |
2003.09.12 |
申请号 |
WO2001GB05774 |
申请日期 |
2001.12.24 |
申请人 |
OXFORD GLYCOSCIENCES (UK) LTD.;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;HERMAN, EUGENE, H.;HOLT, GORDON, D.;SISTARE, FRANK, D.;ZHANG, JUN |
发明人 |
HERMAN, EUGENE, H.;HOLT, GORDON, D.;SISTARE, FRANK, D.;ZHANG, JUN |
分类号 |
A61K38/00;C07K14/47;G01N33/50;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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