USE OF TRANSCRIPTION FACTOR NAK-1 OR GENES REGULATED BY TRANSCRIPTION FACTOR NAK-1 FOR THE DIAGNOSIS AND/OR THERAPY OF INFLAMMATORY AND MALIGNANT DISEASES

摘要

The interaction of the PAI-4 promoter region with NAK-1 was doubly detected by a genetic screen. NAK-1 is up-regulated by a NF kappa B-dependent mechanism in some inflammation reactions but not in others, however NAK-1 stimulates the expression of PAI-1 in both cases. In the inflammation reaction the up-regulation of PAI-1 follows that of NAK-1 and increased NAK-1 binding to the PAI-1 promoter may be detected. NAK-1 is up-regulated in atherosclerotic vessels, where PAI-1 is strongly expressed in the same cells.