发明名称 |
MEANS AND METHODS FOR MANIPULATING HYPERSENSITIVITY-LIKE RESPONSES |
摘要 |
Immunoglobulin light chains (Ig-LC) are produced in excess in animals compar ed to heavy chains. The present invention implicates these Ig-LC in hypersensitivity responses and provides means and methods for manipulating t he responses. The invention further provides a common gamma chain independent receptor on mast cells capable of mediating the mentioned effects of Ig-LC. In response to activation of the pathway of which the found receptor is a part, a mast cell is activated and stimulated to degranulate. |
申请公布号 |
CA2478649(A1) |
申请公布日期 |
2003.09.12 |
申请号 |
CA20032478649 |
申请日期 |
2003.03.05 |
申请人 |
FORNIX BIOSCIENCES N.V. |
发明人 |
NIJKAMP, FRANCISCUS PETRUS;REDEGELD, FRANCISCUS ANTONIUS MARIA;VIDARSSON, GESTUR;VAN DE WINKEL, JOHANNES GERARDUS JOSEPH;KRANEVELD, ALETTA DESIREE |
分类号 |
A61K38/17;A61P37/00;C07K14/705;C07K16/00;C12N5/06;C12N5/08;C12N15/12;G01N33/50 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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