| 摘要 |
<p>The present invention relates to a method for identifying compounds capable of affecting the activity of members of a Mycobacterium serine/threonine kinase family. A new method of developing drugs for treating M. tuberculosis is provided. Unique kinases (PknB, PknG, PknH, PknJ) to the organism are used to discover compounds capable of inhibiting them. Knockout mutants of the respective kinases display slower growth and viability both in vitro and in vivo. These observations are particularly noticeable in the case of pknG mutants.</p> |
