发明名称 |
A METHOD FOR TREATING ALLERGIC DISEASE AND ASTHMA BY RECOMBINANT ADENOVIRUS-AND ADENO-ASSOCIATED VIRUS-MEDIATED IFN-Y GENE |
摘要 |
The subject invention concerns an effective therapy for asthma, including allergic disease, using cytokine gene expression therapy. The subject invention further pertains to the use of adenovirus-mediated IFN-,gamma (Ad-IFN-,gamma) gene transfer to prevent or treat allergic disease and asthma, including associated conditions such as allergen-induced airway inflammation and airway hyperresponsiveness. The subject invention includes a method for effectively attenuating allergen-induced airway inflammation and airway hyperresponsiveness by administering to the respiratory tract Ad-IFN--gamma, to affect IL-12 and STAT-4 levels. The subject invention also provides compositions for gene therapy for asthma by the transfer of IFN-gamma
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申请公布号 |
WO03074561(A1) |
申请公布日期 |
2003.09.12 |
申请号 |
WO2003US06535 |
申请日期 |
2003.03.03 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;MOHAPATRA, SHYAM, S.;KUMAR, MUKESH;BEHERA, ARUAN, K. |
发明人 |
MOHAPATRA, SHYAM, S.;KUMAR, MUKESH;BEHERA, ARUAN, K. |
分类号 |
A61K38/21;A61K48/00;C12N15/861;C12N15/864;(IPC1-7):C07K14/57;C12N15/86 |
主分类号 |
A61K38/21 |
代理机构 |
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地址 |
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