发明名称 LOCAL PRODUCTION AND/OR DELIVERY OF ANTI-CANCER AGENTS BY STROMAL CELL PRECURSORS
摘要 The present invention concerns the use of compositions comprising, and methods for making, genetically modified mesenchymal stem cells to treat subjects with hyperproliferative disorders. Certain embodiments allow local delivery of an agent while avoiding systematic delivery of the agent alone. Stromal precursor cells may be used to produce a biological agent locally at tumour sites. The tumor microenvironment, or other proliferation inducing microenvironment, preferentially promotes the engraftment of stromal precursors as compared to other tissues.
申请公布号 WO03073998(A2) 申请公布日期 2003.09.12
申请号 WO2003US06364 申请日期 2003.02.28
申请人 BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;STUDENY, MATUS;ANDREEFF, MICHAEL;MARINI, FRANK, C. 发明人 STUDENY, MATUS;ANDREEFF, MICHAEL;MARINI, FRANK, C.
分类号 C12N15/09;A61K35/12;A61K35/76;A61K38/19;A61K38/21;A61K48/00;A61P35/00;A61P35/02;A61P35/04;C12N5/0775;C12N5/10;C12N15/861;C12N15/864 主分类号 C12N15/09
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