P387L variant in protein tyrosine phosphatase-1B is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

摘要

The present invention provides an isolated polynucleotide molecule comprising a nucleotide sequence encoding PTP-1B, said nucleotide sequence containing a mutation associated with type 2 diabetes of at least one nucleotide, or comprising a fragment of the<custom-character file="US20030170660A1-20030911-P00999.TIF" wi="151.6" he="8.4" id="custom-character-00001" alt="text missing or illegible when filed"/>