发明名称 |
Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols |
摘要 |
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.
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申请公布号 |
US2003171576(A1) |
申请公布日期 |
2003.09.11 |
申请号 |
US20020268660 |
申请日期 |
2002.10.11 |
申请人 |
KINNEY WILLIAM A.;ZHANG XUEHAI;MICHALAK RONALD |
发明人 |
KINNEY WILLIAM A.;ZHANG XUEHAI;MICHALAK RONALD |
分类号 |
C07B61/00;C07J9/00;C07J21/00;C07J31/00;C07J41/00;(IPC1-7):C07J21/00 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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