Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase

摘要

Compositions and methods for diagnosis of neoplastic tissue are described. Monoclonal antibodies which specifically recognize the tumor cell specific NADH:protein thiol reductase and the hybridoma cell lines which produce them are provided. Also provided are diagnostic and immunohistological assays for the identification of cells that are neoplastic. Because the antibodies specifically prevent the growth of cancer cells, induce apoptotic cell death of cancer cells, and are without effect on normal cells, the described monoclonal antibodies are useful for inhibiting cancer cell growth and for treating a neoplastic condition.