发明名称 |
Process for the synthesis of sphingosine |
摘要 |
This invention relates to a method for the production of a sphingoid base according to formula comprising the steps of (1) dissolving a starting compound according to formula III or a salt thereof in a substantially inert solvent, (2) protecting the NH2 group with a NH2 protecting group, (3) activating the C-4 HR<3 >group for an elimination reaction with the C-5 HR<4 >group, (4) causing an elimination reaction to take place to form a double bond between the C-4 and C-5 carbon atom, and (5) removing the NH2 protecting group.
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申请公布号 |
US2003171621(A1) |
申请公布日期 |
2003.09.11 |
申请号 |
US20020325279 |
申请日期 |
2002.12.20 |
申请人 |
VAN BOOM JACOBUS HUBERTUS;VAN DEN BERG RICHARD |
发明人 |
VAN BOOM JACOBUS HUBERTUS;VAN DEN BERG RICHARD |
分类号 |
C07D263/14;C07C213/08;C07C215/24;C07C247/04;C07C247/08;C07D413/04;C07F7/08;(IPC1-7):C07C213/08 |
主分类号 |
C07D263/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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