Use and targeting of CD98 light-chain proteins in therapies for thyroid hormone disorders

摘要

The invention is related to the normalization of thyroid hormone transport by modulation of 4F2hc, CD98lc, and the 4F2hc-CD98lc heterodimer. Approaches to identify compounds that modulate thyroid hormone disorders, methods of identifying agonists and antagonists that modulate thyroid hormone disorders, and methods of making pharmaceuticals that ameliorate a thyroid hormone disorder are described herein.