8-Aryl-1,7-naphthyridine derivatives, pharmaceutical compositions containing them, their use and process for the preparation and intermediates used in this process

摘要

Novel 8-aryl-1,7-naphthyridines, in free or salt form, are PDE IV inhibitors and are thus useful as pharmaceuticals, e.g. for asthma therapy. Preferred compounds include compounds of formulae (I) and (II) wherein the R groups are as defined. Pharmaceutical compositions comprising the compounds, processes for preparation of the compounds and novel intermediates for use in the processes are disclosed.