Treatment of respiratory conditions associated with bronchoconstriction with aerosolized hyaluronic acid

摘要

A method is disclosed for treating and/or preventing bronchoconstriction induced by neutrophil elastase and tissue kallikrein activity. The method includes administration of aerosolized hyaluronic acid in an amount sufficient to bind to RHAMM (CD168) receptors along the apical surface of the airway epithelium, wherein the hyaluronic acid binds and retains secreted tissue kallikrein, thereby treating and/or preventing bronchoconstriction due to kallikrein activity.