发明名称 TETRALONE DERIVATIVES AS ANTITUMOR AGENTS.
摘要 <p>The present invention provides compounds of formula I and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds have histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment. Also provided is a process for making a compound of formula I by reacting a compound of formula III with a compound of formula IV wherein A is a displaceable group and PG is a protecting group.</p>
申请公布号 MXPA03004947(A) 申请公布日期 2003.09.10
申请号 MX2003PA04947 申请日期 2001.12.06
申请人 F. HOFFMANN-LA ROCHE AG 发明人 ULRICH TIBES
分类号 A61P35/00;A61K31/165;A61K31/166;A61K31/235;A61P35/02;A61P43/00;C07C259/06;C07D213/50;C07D295/116;(IPC1-7):A61K31/165 主分类号 A61P35/00
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