发明名称 METHOD AND DEVICE FOR OBSERVING MINUTE AND THREE- DIMENSIONAL LOCALIZATION OF IN-VIVO EXPRESSED GENE
摘要 PROBLEM TO BE SOLVED: To assume the whole of an individual organism as a target domain of observation and to observe the localization of in-vivo expression genes in a minute domain of a single cell level in the target domain of observation. SOLUTION: This method has a first step for sequentially pushing out, in a fixed direction, genetically-modified biospecimens each having a marker potentiating the detection of a specific gene in its expression, a second step for sequentially cutting off the specimens pushed out in the first step, a third step for condensing light onto a cross section of each specimen cut off in the second step and imaging a two-dimensional picture of the cross section by using reflected light from the cross section onto which light is condensed, and a fourth step for three-dimensionally observing each specimen based on the picture imaged in the third step. COPYRIGHT: (C)2003,JPO
申请公布号 JP2003254964(A) 申请公布日期 2003.09.10
申请号 JP20020057963 申请日期 2002.03.04
申请人 INST OF PHYSICAL & CHEMICAL RES 发明人 YOKOTA HIDEO;NAKAMURA SAKIKO;MAKINOUCHI AKITAKE;HIGUCHI TOSHIRO;HIMENO RYUTARO
分类号 G01N33/483;C12M1/00;C12Q1/02;G01N1/06;(IPC1-7):G01N33/483 主分类号 G01N33/483
代理机构 代理人
主权项
地址