发明名称 |
Methotrexate adjuvants to reduce toxicity and methods for using the same |
摘要 |
Methods are provided for using methotrexate (MTX) active agents in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of an MTX active agent in conjunction with a MTX toxicity-reducing adjuvant, such as a 2,2′-anhydropyrimidine, a derivative thereof or a uridine phosphorylase inhibitor. Also provided are compositions and kits that find use in practicing embodiments of the invention. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions. |
申请公布号 |
US9382287(B2) |
申请公布日期 |
2016.07.05 |
申请号 |
US201414507622 |
申请日期 |
2014.10.06 |
申请人 |
Tosk, Inc. |
发明人 |
Garland William A.;Frenzel Brian D.;Karg Travis |
分类号 |
A61K31/519;C07H19/24;A61K31/7068;A61K45/06 |
主分类号 |
A61K31/519 |
代理机构 |
Bozicevic, Field & Francis LLP |
代理人 |
Field Bret E.;Bozicevic, Field & Francis LLP |
主权项 |
1. A kit for use in treating a host suffering from a cellular proliferative disease condition, said kit comprising:
(a) an MTX active agent; and (b) an MTX toxicity-reducing adjuvant, wherein said MTX toxicity-reducing adjuvant is a 2,2′-anhydropyrimidine or derivative thereof. |
地址 |
Mountain View CA US |