发明名称 |
Nucleoside monophosphate derivative, a processor for their production and their use as immunosuppressive drugs |
摘要 |
<p>The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) <CHEM> wherein R<1> may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R<2> may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X represents sulfur, a sulfinyl or sulfonyl group;and Nucl. represents 2',3'-Didesoxy-2',3'-difluorothymidine 2'-Desoxy-2'-aminoadenosine 2'-Desoxy-2'-azidoadenosine 2'-Desoxy-2'-azidocytidine 2'-Desoxy-5-fluorouridine 2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.</p> |
申请公布号 |
EP1229040(B1) |
申请公布日期 |
2003.09.10 |
申请号 |
EP20020008360 |
申请日期 |
1995.05.23 |
申请人 |
HEIDELBERG PHARMA HOLDING GMBH |
发明人 |
HERRMANN, DIETER;ZILCH, HARALD;MERTENS, ALFRED |
分类号 |
A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61P31/12;A61P35/00;A61P37/06;C07H19/04;C07H19/10;C07H19/20;C07H19/207;(IPC1-7):C07H19/10 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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