| 发明名称 |
Human Rnase H1 and oligonucleotide compositions thereof |
| 摘要 |
The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
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| 申请公布号 |
US6617442(B1) |
申请公布日期 |
2003.09.09 |
| 申请号 |
US19990409926 |
申请日期 |
1999.09.30 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
CROOKE STANLEY T.;LIMA WALTER F.;WU HONGJIANG;MONOHARAN MUTHIAH |
| 分类号 |
C07H21/00;C12N9/22;C12N15/113;(IPC1-7):C07H21/04;C07H21/02;C12Q1/68;C12P19/34 |
主分类号 |
C07H21/00 |
| 代理机构 |
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