Antisense modulation of GCGR expression

摘要

Provided herein are methods, compounds, and compositions for reducing expression of GCGR mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate metabolic disease, for example, diabetes, or a symptom thereof.

主权项

1. A compound comprising a modified oligonucleotide 17 to 30 linked nucleosides in length and having a nucleobase sequence comprising the sequence of SEQ ID NOs: 17, 31, 81, 82 or 85, wherein said modified oligonucleotide is complementary to SEQ ID NO: 2, and wherein said modified oligonucleotide comprises at least one modified internucleoside linkage.