| 发明名称 | Method for amplifying NK cells | ||
| 摘要 | A technique is needed which can amplify NK cells in vitro and prepare optimum number of NK cells for the adoptive immunotherapy.;A method for amplifying NK cells is provided which comprises steps of: preparing cell population which is comprised of NK cells, removing T cells from the cell population which is comprised of NK cells, and, after removal of T cells, cultivating the remaining cells in a medium supplemented with 2500 to 2831 IU/mL of IL-2. The method for amplifying NK cells of the present invention may comprise a step of removing hematopoietic progenitor cells from the cell population. The present invention provides a pharmaceutical composition for adoptive immunotherapy, comprising NK cells which are prepared by the amplifying method of the present invention. | ||
| 申请公布号 | US9404083(B2) | 申请公布日期 | 2016.08.02 |
| 申请号 | US201214129143 | 申请日期 | 2012.06.20 |
| 申请人 | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION;TELLA, INC. | 发明人 | Yonemitsu Yoshikazu;Harada Yui;Saito Satoru;Yazaki Yuichiro;Okamoto Masato;Ishidao Takefumi |
| 分类号 | A61K35/28;A61K38/00;C12N5/0783;A61K35/17 | 主分类号 | A61K35/28 |
| 代理机构 | Buchanan, Ingersoll & Rooney PC | 代理人 | Buchanan, Ingersoll & Rooney PC |
| 主权项 | 1. A method for amplifying NK cells, comprising the steps of: preparing cell population which is comprised of NK cells; removing T cells from the cell population which is comprised of NK cells; and after removal of T cells, cultivating the remaining cells without feeder cells in a medium supplemented with 2500 to 2831 IU/mL of IL-2, as the only cytokine. | ||
| 地址 | Fukuoka JP | ||