发明名称 |
MAP kinases: polypeptides, polynucleotides and uses thereof |
摘要 |
The present invention relates to a method of identifying a compound which blocks the activation of a stress-activated protein kinase selected from the group consisting of SAPK4 and SAPK3 by SKK3. The method includes contacting the stress-activated protein kinase with the compound and determining whether the compound enhances or disrupts the interaction between the stress-activated protein kinase and SKK3. The invention further relates to a screening assay, a method of identifying agents able to influence the activity of a stress-activated protein kinase and a method of activating a stress-activated protein kinase.
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申请公布号 |
US6617117(B1) |
申请公布日期 |
2003.09.09 |
申请号 |
US20010809464 |
申请日期 |
2001.03.15 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
COHEN PHILIP;GOEDERT MICHEL |
分类号 |
C12N15/09;A61K38/00;C07K16/40;C12N9/12;C12Q1/48;(IPC1-7):G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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