| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel compounds of formula I or pharmaceutically acceptable salts thereof, which possess properties of binding Abeta-oligomers with respect to nerve cells in patients. In formula I;Ris (A1); Rand R, each represents H; Rand R, each independently selected from OH and Calkoxy group; Rrepresents H; Rrepresents H, Calkyl, Chalogenalkyl or Ccycloalkyl; Ris Calkyl, Chalogenalkyl or Ccycloalkyl; Rrepresents H or Calkyl; Rrepresents H, Calkyl, Chalogenalkyl or Ccycloalkyl; Rrepresents H; Rand R, each represents H; Ris selected from halogen and Chalogenalkyl; Rand R, each represents H. Preferable compounds are 4-(3-(4-chlorobenzylamino)butyl)-2-methoxyphenol or 4-(3-(4-(trifluoromethyl)benzylamino)butyl)-2-methoxyphenol. Said compounds are obtained by reacting a ketone of formula X with an amine of formula XI;under reductive amination conditions with separation of corresponding compounds. Output of products is 80-95 wt%. Ginger oil containing a ketone of formula X can be used as a starting compound.EFFECT: compounds can be useful in treating cognitive abilities, for example in Alzheimer's disease.18 cl, 4 dwg, 8 ex |
