| 发明名称 |
ASSAYS FOR DETERMINING PLASMA KALLIKREIN SYSTEM BIOMARKERS |
| 摘要 |
Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system. |
| 申请公布号 |
US2016252527(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201415030811 |
申请日期 |
2014.10.17 |
| 申请人 |
DYAX CORP. |
发明人 |
Sexton Daniel J.;Faucette Ryan;Kenniston Jon A.;Conley Gregory P.;Nixon Andrew;TenHoor Christopher;Adelman Burt |
| 分类号 |
G01N33/68;C07K16/40;C12Q1/37 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An ex vivo activation method, comprising:
incubating a plasma sample obtained from a subject with an activator of the plasma kallikrein (pKal) system; measuring the levels of intact high molecular weight kininogen (HMWK), cleaved HMWK, or both, in the plasma sample before and after the incubation; and determining the reduction of intact HMWK in the sample after the activation. |
| 地址 |
Burlington MA US |
