| 摘要 |
<p>Oral trimethobenzamide compositions and methods for treating and controlling nausea and/or vomiting are disclosed in warm blooded animals, especially humans including children. The oral trimethobenzamide compositions and methods of the present invention are at least as effective as a 200 mg intramuscular (I.M.) trimethobenzamide HC1 injectable formulation. In addition, an oral composition containing about 300 mg of trimethobenzamide HC1 is uniquely approximately bioequivalent to a 200 mg intramuscular (I.M.) trimethobenzamide HC1 injectable formulation. The oral pediatric trimethobenzamide compositions and methods of the present invention are believed to be at least as effective as a 200 mg intramuscular (I.M.) trimethobenzamide HC1 injectable formulation when administered at a dose of about 100 mg. In addition, an oral pediatric composition containing about 120 mg of trimethobenzamide HC1 is believed to be uniquely approximately bioequivalent to a 200 mg intramuscular (I.M.) trimethobenzamide HC1 injectable formulation when administered at a dose of about 100 mg.</p> |
