NOVEL TRANS-VIRAL VECTORS COMPRISING MULTICISTRONIC EXPRESSION CONSTRUCTS AND METHODS OF USE
摘要
The present invention provides novel methods and compositions for the expression of a polypeptide of interest. In particular, the methods and compositions of the invention combine a trans-viral vector system (Figure 1) with a gene transfer vector having at least one DNA expression cassette comprising multiple open reading frames separated by internal ribosomal entry sites (IRES) or an active fragment or variant thereof.
申请公布号
WO03072797(A1)
申请公布日期
2003.09.04
申请号
WO2003US05598
申请日期
2003.02.24
申请人
TRANZYME, INC.;UAB RESEARCH FOUNDATION;WAKEFIELD, JOHN, K.;KAPPES, JOHN, C.;WU, XIAOYUN