NOVEL COUPLING AGENTS, THE ACTIVE INTERMEDIATES AND THE CONJUGATES THEREOF AND THE USE OF SAID CONJUGATES IN DIAGNOSTIC METHODS

摘要

The invention relates to coupling agents of the following general formula (I), the active intermediates comprising a coupling agent as above and either a molecule with at least one aldehyde or ketone function at the surface thereof before conjugation or one to eight molecules with at least one free thiol function at the surface thereof before conjugation. The conjugates comprise a coupling agent as above, a molecule with at least one aldehyde and/or ketone function at the surface thereof and one to eight molecules with at least one free thiol function at the surface thereof. The invention further relates to the use of said conjugates in in vitro diagnostic methods for diseases, using recognition of a ligand/anti-ligand couple.