PHARMACEUTICAL DOSAGE FORMS COMPRISING TABLET CORE HAVING A TENSILE STRENGTH BELOW 38 N/SQCM AND A COATING TO PROTECT THE SOFT CORE

摘要

A pharmaceutical dosage form comprising: a) a tablet core comprising a pharmaceutically active ingredient and one or more pharmaceutically active ingredient and one or more pharmaceutically acceptable adjuvants, the tablet core having a tensile strength of less than 38 N/cm2 before coating and fusi on and b) a coating extending over at least 25% of the surface area of the tabl et core, the coating resulting from deposition of a powder comprising fusible particles and fusing the particles to form a coating film, thereby providing the pharmaceutical dosage form with a greater hardness/crush strength than t he tablet core. The tablet core may be formed by light compression with enables coated components and fragile components, such as capsules, to be used withi n the compression blend with little or no damage.