发明名称 |
Chimeric adenoviral fiber protein and methods of using same |
摘要 |
A recombinant adenovirus comprising a chimeric adenoviral fiber protein comprising a non-adenoviral amino acid sequence in place of or in addition to a native fiber amino acid sequence, wherein the chimeric adenoviral fiber protein comprises a trimerization domain and the non-adenoviral amino acid sequence is of a size such that folding of the chimeric adenoviral fiber protein and assembly of a complex comprising the chimeric adenoviral fiber protein and a penton base is not impeded, and an adenoviral transfer vector for the generation of such a recombinant adenovirus are provided.
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申请公布号 |
US2003166286(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
US20020173930 |
申请日期 |
2002.06.17 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
WICKHAM THOMAS J.;FALCK-PEDERSEN ERIK;ROELVINK PETRUS W.;BRUDER JOSEPH T.;GALL JASON;KOVESDI IMRE |
分类号 |
C12N15/09;A61K35/76;A61K48/00;C07K14/075;C07K19/00;C12N7/00;C12N7/01;C12N15/861;(IPC1-7):C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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