发明名称 |
FORMULATION STRATEGIES IN STABILIZING PEPTIDES IN ORGANIC SOLVENTS AND IN DRIED STATES |
摘要 |
The invention relates to stabilized formulations of therapeutically active peptides, particularly PACAP 66. Formulations of the invention include a peptide containing at least one histidine residue, a transition metal salt and an organic solvent. The above formulations may contain peptides that have at least one asparagine residue and are acidified and dried (such as spray-dried or freeze-dried) before formulation preparation. Other formulations of the invention relate to stabilized formulations of PACAP 66 or peptides containing an asparagine residue, which are acidified and dried (such as spray-died or freeze-dried) with or without a transition metal salt. |
申请公布号 |
AU2003219787(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
AU20030219787 |
申请日期 |
2003.02.14 |
申请人 |
BAYER PHARMACEUTICALS CORPORATION |
发明人 |
WEI WANG;YU-CHANG, JOHN WANG;SHERYL MARTIN-MOE |
分类号 |
A61K9/19;A61K38/22;A61K47/02;A61K47/10;A61K47/12;A61K47/14;A61K47/18;A61K47/20;A61K47/22;C07K14/575 |
主分类号 |
A61K9/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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