发明名称 |
Targeted replacement of a gene without endogenous and selectable residual sequences |
摘要 |
Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with human genes, either through conventional gene targeting, or by use of the bacteriophage-derived Cre-loxP recombination system. The transgenic animals undergo antibody affinity maturation, and a class switch from the native immunoglobulin to the humanized form.
|
申请公布号 |
US2003167489(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
US20020272358 |
申请日期 |
2002.10.15 |
申请人 |
RAJEWSKY KLAUS;ZOU YONG-RUI |
发明人 |
RAJEWSKY KLAUS;ZOU YONG-RUI |
分类号 |
A01K67/027;A61K38/00;C07K16/00;C12N5/10;C12N15/09;C12N15/90;C12P21/08;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|