摘要 |
A compound consisting of an oligonucleotide of sequence CAGCAGCAGAGTCTTCATCAT, where the oligonucleotide has a phosphorothioate backbone throughout, the sugar moieties of nucleotides 1-4 and 18-21 bear 2'-O-methoxyethyl modifications, and the remaining nucleotides nucleotides 5-17 are 2'-deoxynucleotides, and where the cytosines of nucleotides 1, 4 and 19 are 5-methylcytosines. The compound has increased stability in vivo and improved in vitro and in vivo antitumor activity.
|
申请人 |
UNIVERSITY OF BRITISH COLUMBIA;GLEAVE, MARTIN;RENNIE, PAUL, S.;MIYAKE, HIDEAKI;NELSON, COLLEEN;MONIA, BRETT, P. |
发明人 |
GLEAVE, MARTIN;RENNIE, PAUL, S.;MIYAKE, HIDEAKI;NELSON, COLLEEN;MONIA, BRETT, P. |