发明名称 |
Mice heterozygous for WFS1 gene as mouse models for depression |
摘要 |
The present invention describes a recombinant rodent model for depression. More particularly, the rodent comprises cells expressing mutations in the WFS1 gene. The rodent is preferably a mouse heterologous for mutations in exon 8 of the WFS1 gene. Preferably, the mutations yield a non-functional wolframin protein that lacks all or some of it transmembrane regions. Methods and compositions for making and using the mouse and cells thereof are disclosed.
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申请公布号 |
US2003167488(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
US20020195963 |
申请日期 |
2002.07.16 |
申请人 |
ROBERDS STEVEN L.;HUFF RITA M. |
发明人 |
ROBERDS STEVEN L.;HUFF RITA M. |
分类号 |
C07K14/705;C12N15/85;(IPC1-7):A01K67/027 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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